Seminar - Murray Deutscher

photo of Dr. Murray Deutscher
September 24, 2018 - 12:00pm
Location: 
601 Fairchild

Professor

Department of Biochemistry and Molecular Biology

University of Miami Miller School of Medicine

Host: John Hunt

Title: How Cells Keep Ribonucleases Under Control: Post-translational Regulation of RNase R

Abstract: Ribonuclease are essential in almost every aspect of RNA metabolism, but they are also destructive enzymes that must be kept under control to avoid unwanted RNA destruction. In this seminar I will discuss the growth phase-dependent regulation of the important exoribonuclease, RNase R. This complex process involves components of the trans-translation machinery, post-translational modification, ribosomes and proteolysis. This novel regulatory process is just one of several recently-discovered mechanisms that cells use to control their ribonuclease repertoire.

News and Research Highlights

Researchers found clumps of non-functioning hnRNP H and at least three other RNA-binding proteins in the brain cells of people who had died with ALS, frontotemporal dementia or both. Bright red clumps of hnRNP H can be seen in the spinal cord motor neurons at left. Healthy neurons are shown at right. (Images: Aarti Sharma /Columbia University)
August 27, 2018 - 10:30am

Researchers found clumps of non-functioning hnRNP H and at least three other RNA-binding proteins in the brain cells of people who had died with ALS, frontotemporal dementia or both.

August 14, 2018 - 3:45pm

The schedule for seminars in fall 2018 has been released.

June 4, 2018 - 11:30am

Molly Przeworski was awarded the Distinguished Columbia Faculty Award for exceptional teaching

Figure Divergent Vocalizations
May 25, 2018 - 11:15am

The vertebrate hindbrain includes multiple neural circuits that generate rhythmic behaviors including vocalizations.

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