Seminar - Virginie Courtier-Orgogozo

photo of Dr. Virginie Courtier-Orgogozo
September 19, 2018 - 12:00pm
Location: 
601 Fairchild

CNRS

Institut Jacques Monod

Universitié Paris 7

Host: Peter Andolfatto

Title: Chance and predictability in the genetic paths of evolution

Abstract: To better understand the evolution of populations and species it is important to identify the genes and the mutations responsible for evolutionary changes. Using closely related species of Drosophila, we identified nucleotide substitutions that have occurred during evolution, each one contributing to several phenotypic changes. Our results challenge the idea that cis-regulatory enhancers are strict tissue-specific modules underlying evolutionary changes in targeted traits. The possible paths of evolution thus appear to be constrained by pleiotropic nucleotide sites in genomes.

Gephebase.org is a manually curated online database that consolidates data from the scientific literature about the genes and the mutations responsible for phenotypic variation in animals, yeasts and plants. Gephebase compiles a total of 96 associations between a precise cis-regulatory mutation and an evolutionary phenotypic change (based on linkage mapping). Among these 96 cases, interspecific evolution involves fewer indels and more single nucleotide changes than intraspecific evolution. These results suggest that indels in cis-regulatory regions are more deleterious than SNPs and that enhancers are more pleiotropic than previously thought.

News and Research Highlights

Researchers found clumps of non-functioning hnRNP H and at least three other RNA-binding proteins in the brain cells of people who had died with ALS, frontotemporal dementia or both. Bright red clumps of hnRNP H can be seen in the spinal cord motor neurons at left. Healthy neurons are shown at right. (Images: Aarti Sharma /Columbia University)
August 27, 2018 - 10:30am

Researchers found clumps of non-functioning hnRNP H and at least three other RNA-binding proteins in the brain cells of people who had died with ALS, frontotemporal dementia or both.

August 14, 2018 - 3:45pm

The schedule for seminars in fall 2018 has been released.

June 4, 2018 - 11:30am

Molly Przeworski was awarded the Distinguished Columbia Faculty Award for exceptional teaching

Figure Divergent Vocalizations
May 25, 2018 - 11:15am

The vertebrate hindbrain includes multiple neural circuits that generate rhythmic behaviors including vocalizations.

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