Seminar - Stephen Floor

photo of Dr. Stephen Floor
October 21, 2019 - 12:00pm
601 Fairchild

Assistant Professor

Department of Cell and Tissue Biology

University of California, San Francisco

Host: Marko Jovanovic

Title: RNA Chaperones Remodel Gene Expression

Abstract: RNA chaperones are enzymes that remodel RNA structures and RNA protein complexes. I will present recent work on how RNA chaperones affect gene expression, and how these processes are altered in diseases. The output of a gene is affected at the translational level through RNA structures and trans-acting RNAs and proteins. We find that the RNA chaperone DDX3 controls translation of a subset of mRNAs that are enriched in RNA structures. DDX3 is mutated or changes in expression level in cancers and developmental disorders. I will discuss how changes to DDX3 remodel the output of the transcriptome in both cancer and developmental disorders.

News and Research Highlights

Photo credit: Alex Wild
October 7, 2019 - 12:15pm

Dr. Laura Duvall, one of the Biology Department's newest Faculty members, recently wrote an article for Columbia News about Eastern Equine Encephalitis (EEE).

Emily Bayer is pictured at a lab bench
September 18, 2019 - 10:00am

Emily Bayer, a graduate student in the Hobert lab, was one of three young scientists presented the International Birnstiel Award.

Prize-winning students
July 19, 2019 - 3:45pm

The Department of Biological Sciences is proud to present its annual awards and prizes to eight graduate students in recognition of their stellar academic achievements and service to their community. Congratulations!

photo of Prof. Martin Chalfie
May 7, 2019 - 1:30pm

Dr. Martin Chalfie, University Professor, has been awarded this year's Lomonosov Gold Medal 

April 11, 2019 - 9:45am

Established in 1970 in honor of David B. Truman, former Dean of the College, the David B.

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