Talk Title: Multi-scale metabolic and cellular map of liver using spatial imaging technologies
Talk Abstract: Understanding of the spatial organization of cellular neighborhoods and their molecular composition is essential to understand normal tissue function as well as dysfunction. Liver, a critical metabolic hub within the body, exhibit metabolic zonation to facilitate various localized functions. I will be discussing our recent work implementing multimodal imaging technologies for metabolic and cellular spatial characterization of healthy mouse and human liver tissue. Our workflow utilizes multi-scale mass spectrometry imaging technologies to detect lipids and metabolites, in addition to multiplexed-antibody based imaging for mapping cellular phenotypes within functional liver zones.