Department of Basic Neuroscience
Geneva University
Title: Synaptic basis of fentanyl addiction: from pharmacology to blueprints of novel treatments
Abstract: Addictive drugs have in common that they boost dopamine in the mesolimbic system. We will examine the underlying cellular mechanism, in particular of the rapidly acting opioid fentanyl, and describe the ensuing modulatory effects on glutamate transmission. We will then consider the chronic use of opioids, which leads to loss of control in some individuals. We will discuss rodent models based on optogenetic mimicry of fentanyl pharmacology. We will describe the emerging circuit model and the blueprints for rational drug addiction treatments.
Host: Raju Tomer
