Alice Heicklen

Alice Heicklen

Full Research Description

Post Doctorate/Instructor- The Albert Einstein College of Medicine, Sept. 2000-2004, NIH Cardiovascular fellowship /American Heart Association Scientific Development Fellowship. Aberrant heart development and maintenance are major causes of miscarriages and heart failure. I have created Zebrafish lines using GATA-4 and GATA-6 regulatory regions to reveal in real time the role of these GATA factors in heart development and disease.

Education

Phd., Weizmann Institute of Science, Israel, July 2000, Transcriptional regulationof the microtubule associated protein, tau and its deregulation in Alzheimer's disease. Outstanding student award.

Advisor: Dr. Irith Ginzburg

M.S. Tel Aviv University, Israel, March 1991, Intermodal compensation in the neonatally enucleated Syrian hamster. Honors

B.A. Penn State University, May 1988. Honors

Representative Publications

  1. Thaker, M., Cabrera, M and Heicklen-Klein, A. KR612324 Gypsophila paniculata Glyceraldehyde-3-Phosphate Dehydrogenase (GAPC2) gene, partial cds 2015
  2. Cricco-Lizza,E., Lovi-Borgmann,A., Leone,A., Uche,E.C. and Heicklen-Klein,A. KR612325 Bellis perennis Glyceraldehyde-3-Phosphate Dehydrogenase (GAPC1) gene, partial cds 2015
  3. Leone,A., Uche,E.C. and Heicklen-Klein,A. KR612326 Physalis philadelphica Glyceraldehyde-3-Phosphate Dehydrogenase (GAPC2) gene, partial cds 2015
  4. Leone,A., Uche,E.C. and Heicklen-Klein,A. KR612327 Physalis philadelphica Glyceraldehyde-3-Phosphate Dehydrogenase (GAPC1) gene, partial cds 2015
  5. Safavi Ardebili, A., Peralta, C., Watanabe, I. Muhammad, H. and Heicklen-Klein, A. KJ852649 Allium cepa glyceraldehye-3-phosphate dehydrogenase (GAPC2) gene, partial cds 2014
  6. Yueh, N., Chang, G., Rancy, S., Kwon, S. and Heicklen-Klein, A. KJ852650 Pastinaca sativa glyceraldehye-3-phosphate dehydrogenase (GAPC1) gene, partial cds 2014
  7. Braffman, N., Nolan, K., Chang, G. Rancy, S. and Heicklen-Klein, A. KJ852651 Citrus limon glyceraldehye-3-phosphate dehydrogenase (GAPC1) gene, partial cds 2014
  8. Escherich, M., Sidikman, Y., Georgakis, F., Habbu, K. and Heicklen-Klein, A. KF282618 Cucumis sativus glyceraldehyde-3-dehydrogenase (GAPC2) gene, Allele with duplication, partial cds 2013
  9. Sidikman, Y., Escherich, M., Georgakis, F., Habbu, K. and Heicklen-Klein, A. KF282617 Cucumis sativus glyceraldehyde-3-dehydrogenase (GAPC2) gene, no duplication allele, partial cds 2013
  10. Escherich, M., Sidikman, Y., Georgakis, F., Habbu, K. and Heicklen-Klein, A. KF282616 Cucumis sativus glyceraldehyde-3-dehydrogenase gene, partial cds 2013
  11. Shaw, A., Mills, N., Qiu, B., Hissourou, M. and Heicklen-Klein, A. KF282615 Anethum graveolens glyceraldehyde-3-dehydrogenase (GAPC2) gene, partial cds 2013
  12. Shaw, A., Mills, N., Qiu, B., Hissourou, M. and Heicklen-Klein, A. KF282614 Anethum graveolens glyceraldehyde-3-dehydrogenase gene, partial cds 2013
  13. Schelke, M. Nichols, A. and Heicklen-Klein, A. KF282613 Mentha spicata glyceraldehyde-3-dehydrogenase (GAPC2) gene, partial cds 2013
  14. Vlahos, M., Lazarovici, A. and Heicklen-Klein, A. JN083805 Eruca vesicaria subsp. sativa glyceraldehyde-3-phosphate dehydrogenase (GAPC1) gene, partial cds. 2011
  15. Barnett, A., Huang, A., Lazarovici, A., Constant, C., Nsibirwa, N. and Heicklen-Klein, A. JN083806 Salvia officinalis glyceraldehyde-3-phosphate dehydrogenase (GAPC2) gene, partial cds. 2011
  16. Amaniera, F., Samant, R. and Heicklen-Klein, A. JN086968 Daucus carota glyceraldehyde-3-phosphate dehydrogenase (GAPC1) gene, partial cds. 2011
  17. Vhalos, M., Garg, K., Leiner, A., Leonardo, T. and Heicklen-Klein, A. JN086969 Daucus carota glyceraldehyde-3-phosphate dehydrogenase (GAPC2) gene, partial cds. 2011
  18. Kachniarz, B., Levites, H., Lefkowitz, A. and Heicklen-Klein, A. HM228871 Spinacia oleracea glyceraldehyde-3-phosphate dehydrogenase (GAPC) gene, partial cds. 2010
  19. Kachniarz, B., Levites, H., White, P. and Heicklen-Klein, A. HM228872 Solanum lycopersicum glyceraldehyde-3-phosphate dehydrogenase (GAPC) gene, partial cds. 2010
  20. Heicklen-Klein A., McReynolds L.J. and Evans T. (2005) Using the zebrafish model to study GATA transcription factors, Semin. Cell Dev. Biol.16: 95-106
  21. Heicklen-Klein A. and Evans T. (2004) T-Box binding sites are required for activity of a cardiac GATA-4 enhancer. Dev. Biol. 267: 490-504
  22. Izraeli R., Koay G., Lamish M., Heicklen-Klein A., Heffner H. E., Heffner R. S.  and Wollberg Z. (2002) Cross-modal neuroplasticity in blind hamsters: structure, electrophysiology, and behavior. Eur. J. Neurosci. 15:693-712.
  23. Heicklen-Klein A. and Ginzburg I. (2000) Tau promoter confers neuronal specificity and binds Sp1 and AP-2. J. Neurochem. 75(4): 1408-1418.
  24. Heicklen-Klein A., Aronov S. and Ginzburg I. (2000) Tau promoter activity in neuronally differentiated P19 cells. Mol. Brain Res. 874(1): 1-9.
  25. Sadot E., Heicklen-Klein A.  Barg J., Lazarovici P. and Ginzburg I. (1996) Identification of a tau promoter region mediating tissue-specific-regulated expression in PC12 cells. J. Mol. Biol. 256: 805-812.
  26. Gur S., Ron S., and Heicklen-Klein A. (1994) Objective evaluation of visual fatigue in VDU workers. Occup. Med. 44: 201-204.
  27. Gur S., Ron S., and Heicklen-Klein A. (1992) The need for visual impairment evaluation in VDU workers. Arch. Scienze Lav. 8: 125-129.