Seminar - Abbas Rizvi

photo of Dr. Abbas Rizvi
February 27, 2017 - 12:00pm
Location: 
601 Fairchild

Postdoctoral Fellow

Department of Biochemistry and Molecular Biophysics

Columbia University Medical Center

Host: Joe Pickrell

Title: Delineating Neurogenic Commitment with Single Cell Resolution

Abstract: Cellular lineage commitment results from the induction of dynamically regulated transcriptional programs.  I will present an unbiased approach to studying neurogenesis that combines temporal single cell RNA-sequencing and topology-based computational analyses.  The approach involves a non-linear, model-independent, statistical framework tailored to capture high-dimensional continuous relationships, allowing for the unsupervised characterization of transient cellular states.  As a proof of concept, we applied this workflow to the study of mouse embryonic stem cells (mESCs) as they differentiate into motor neurons, in vitro.  This work demonstrates our ability to resolve asynchrony and continuity in cellular identity over time, along with the identification of transient cellular states based on dynamic changes in stage-dependent combinations of transcription factors, RNA-binding proteins and long non-coding RNAs.

The approach I will discuss has wide applicability to a broad range of biological problems that involve asynchronous or stochastic cellular responses to developmental cues or environmental perturbations.

Click here to see the full schedule of faculty search seminars.

News and Research Highlights

SURF Symposium logo
February 10, 2017 -
12:00pm - 2:00pm

SURF Symposium

October 31, 2016 - 5:00pm

The Department of Biological Sciences has an ongoing search for two faculty positions: one at the Assistant Professor level  in the field of Genomics and one at the Open Rank level in Population Ge

September 27, 2016 - 1:45pm

We are pleased to announce the 3 annual student prizes for excellence and teaching as determined by the departmental graduate committee. This year's prizes are awarded to:

October 6, 2016 - 2:15pm

Da Costa Professor Carol Prives received the 2016 Ernst W. Bertner Memorial Award this month at the Annual Symposium on Fundamental Cancer Research.

Subscribe to Front page feed

Business Office

Department of Biological Sciences
500 Fairchild Center
Mail Code 2401
Columbia University
1212 Amsterdam Avenue
New York, NY 10027

Academic Office

Department of Biological Sciences
600 Fairchild Center
Mail Code 2402
Columbia University
1212 Amsterdam Avenue
New York, NY 10027
biology@columbia.edu
212 854-4581