Department of Biology
Host: Guy Sella
Title: How sensitive are cells to subtle stresses?
Abstract: Cells are like tiny machines with highly integrated systems; it is hard to imagine how they adapt and evolve because changing any trait can influence many other traits and molecular processes, resulting in complex tradeoffs. In this talk, I will discuss experiments in yeast that allow sensitive measurements of how cells respond to subtle genetic or environmental perturbations. These measurements provide quantitative insights into major problems in biology, such as how complex traits (e.g. disease) result from small-effect genetic variants that interact to result in large phenotypic changes.
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