Developmental genetics in Drosophila
During development, cells are programmed to generate and interpret spatial information so that every cell within a population knows where it is and what to do as a consequence. Dr. Struhl's work uses genetical and molecular approaches in Drosophila to address the fundamental questions (i) what is spatial information?, (ii) how is it generated?, and (iii) how is it interpreted? His work has led to discoveries about the nature and mode action of spatial determinants controlling cell and body patterns, tissue growth and planar cell polarity. These include (i) the Polycomb and HOX “selectors” in specifying body segments; (ii) the transcription and translation factors Bicoid, Caudal, Hunchback and Nanos in organizing global body pattern, (iii) secreted factors of the Hedgehog, Wnt, and BMP/TGFb superfamilies as the first, intercellular gradient morphogens, (iv) Delta/Notch signaling in cell-fate specification, and (v) the serpentine receptors Frizzled and Starry night, and the atypical cadherins Dachsous and Fat, in planar cell polarity.
- Langridge P, Struhl G.: (2017) Epsin-dependent ligand endocytosis activates Notch by force. Cell
- Coleman RT, Struhl G.: (2017) Causal role for inheritance of H3K27me3 in maintaining the OFF state of a Drosophila HOX gene. Science 356: pii: eaai8236
- Vrabioiu AM, Struhl G.: (2015) Fat/Dachsous Signaling Promotes Drosophila Wing Growth by Regulating the Conformational State of the NDR Kinase Warts. Dev Cell 35: 737-49
- Parker J, Struhl G.: (2015) Scaling the Drosophila Wing: TOR-Dependent Target Gene Access by the Hippo Pathway Transducer Yorkie. PLoS Biol 13: e1002274
- Struhl G, Casal J, Lawrence PA.: (2012) Dissecting the molecular bridges that mediate the function of Frizzled in planar cell polarity. Development 139: 3665-74
- Zecca M, Struhl G.: (2010) A feed-forward circuit linking wingless, fat-dachsous signaling, and the warts-hippo pathway to Drosophila wing growth. PLoS Biol. 8: e1000386