Tong Lab Reports the cryo-EM Structure of Metabolic Enzyme ACLY

Thursday, April 4, 2019 - 10:15
3D structure of the ACLY tetramer produced using cryo-EM

3D structure of the ACLY tetramer produced using cryo-EM

Photo credit: Liang Tong, Columbia University; Nimbus Therapeutics; Nature

Liang Tong, William R. Kenan, Jr. professor and department chair of Biological Sciences at Columbia, has led a study elucidating the cryo-EM structure of human ATP-citrate lyase (ACLY) in complex with a potent inhibitor developed at Nimbus, which is published this month in Nature. ACLY is a central metabolic enzyme and an attractive drug discovery target against cancer, high cholesterol, and other diseases.

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