Atomic structure of an active human histone pre-mRNA 3'-end processing machinery reported in Science by the Tong lab

Thursday, February 20, 2020 - 11:15
Fig1b A movie showing the function of the histone pre-mRNA 3'-end processing machinery

The Tong lab has reconstituted an active human histone pre-mRNA 3'-end processing machinery, consisting of 13 proteins and 2 RNAs, and determined its structure using cryo-electron microscopy. The structure reveals the overall architecture of the machinery as well as the molecular mechanism for the activation and catalysis of the endonuclease for 3'-end processing.

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