Department of Cell and Tissue Biology
Host: Marko Jovanovic
Title: RNA Chaperones Remodel Gene Expression
Abstract: RNA chaperones are enzymes that remodel RNA structures and RNA protein complexes. I will present recent work on how RNA chaperones affect gene expression, and how these processes are altered in diseases. The output of a gene is affected at the translational level through RNA structures and trans-acting RNAs and proteins. We find that the RNA chaperone DDX3 controls translation of a subset of mRNAs that are enriched in RNA structures. DDX3 is mutated or changes in expression level in cancers and developmental disorders. I will discuss how changes to DDX3 remodel the output of the transcriptome in both cancer and developmental disorders.