Seminar - Joshua Woodward

photo of Dr. Josh Woodward
February 6, 2019 - 12:00pm
Location: 
601 Fairchild

Department of Microbiology

School of Medicine

University of Washington

Host: Liang Tong

Title: Cytosolic RECONnaissance: Host Strategies for Detecting Bacterial Cyclic Dinucleotides

Abstract: Innate immune recognition of colonizing and infecting bacteria has significant impacts in shaping human health and disease. Cyclic dinucleotides of host and bacterial origin have emerged as potent modulators of the immune responses during bacterial and viral infection. We recently identified the host protein RECON as a bacterial specific sensor of cyclic dinucleotides. RECON sensing of these molecules results in elevated pro-inflammatory cytokine production and antimicrobial responses that contribute to bacterial clearance. These findings poise RECON as a major mediator of host responses to bacterial infection and warrant further interrogation of its role in diverse host-microbe contexts.

Business Office

Department of Biological Sciences
500 Fairchild Center
Mail Code 2401
Columbia University
1212 Amsterdam Avenue
New York, NY 10027

Academic Office

Department of Biological Sciences
600 Fairchild Center
Mail Code 2402
Columbia University
1212 Amsterdam Avenue
New York, NY 10027
biology@columbia.edu
212 854-4581