Department of Microbiology
School of Medicine
University of Washington
Host: Liang Tong
Title: Cytosolic RECONnaissance: Host Strategies for Detecting Bacterial Cyclic Dinucleotides
Abstract: Innate immune recognition of colonizing and infecting bacteria has significant impacts in shaping human health and disease. Cyclic dinucleotides of host and bacterial origin have emerged as potent modulators of the immune responses during bacterial and viral infection. We recently identified the host protein RECON as a bacterial specific sensor of cyclic dinucleotides. RECON sensing of these molecules results in elevated pro-inflammatory cytokine production and antimicrobial responses that contribute to bacterial clearance. These findings poise RECON as a major mediator of host responses to bacterial infection and warrant further interrogation of its role in diverse host-microbe contexts.