Seminar - Jared Schrader

photo of Dr. Jared Schrader
February 25, 2019 - 12:00pm
Location: 
601 Fairchild

Assistant Professor

Department of Biological Sciences

Wayne State University

Host: John Hunt

Title: Bacterial RNP-bodies organize mRNA decay

Abstract: Bacteria have distinct challenges to organize their cellular pathways as they generally lack membrane-bound organelles.  In eukaryotes, membraneless organelles called biomolecular condensates provide distinct liquid-liquid phase separated structures that organize cellular components.  We identified bacterial ribonucleoprotein bodies (BR-bodies) as the first biomolecular condensate identified in bacterial cells composed of the RNA degradosome multi-protein complex and cellular RNAs.  Here we will describe how the bacterium Caulobacter crescentus organizes ribonucleases, RNA helicases, and mRNA substrates into BR-bodies which stimulate mRNA decay.  Therefore, we propose that the formation of similar biomolecular condensate organelles may provide a particularly effective strategy for spatially organizing biochemical pathways in bacteria.

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