Host: Iva Greenwald
Title: Regulation of RNA granule assembly by intrinsically-disordered proteins
Abstract: RNA granules are RNA/protein condensates that form in the cytoplasm or nucleoplasm of cells. My laboratory studies the assembly and function of P granules, RNA granules in the germline of C. elegans. I will present evidence that P granule assembly is driven by condensation of mRNAs with intrinsically-disordered proteins that form nanoscale gels. Our findings suggest that RNA-protein gels may be a common strategy to co-localize and segregate large numbers of mRNAs in cells.