Department of Genetics
Host: John Hunt
Title: Use of metabolites as non-canonical initiating nucleotides (NCINs) provides an "ab initio" mechanism for RNA 5' capping
Abstract: Chemical modifications of the RNA 5'-end provide a layer of “epitranscriptomic” regulation, influencing RNA fate, including stability, processing, localization, and translation efficiency. Recently, a new RNA 5'-end modification comprising the metabolic effector nicotinamide adenine dinucleotide (NAD) has been identified on RNAs isolated from bacterial, yeast, and human cells. I will discuss the mechanism of NAD capping and the potential role of NAD capping in directly linking cellular metabolism to gene expression.