Seminar - Bryce Nickels

photo of Dr. Bryce Nickels
December 10, 2018 - 12:00pm
Location: 
601 Fairchild

Professor

Waksman Institute

Department of Genetics

Rutgers University

Host: John Hunt

Title: Use of metabolites as non-canonical initiating nucleotides (NCINs) provides an "ab initio" mechanism for RNA 5' capping

Abstract: Chemical modifications of the RNA 5'-end provide a layer of “epitranscriptomic” regulation, influencing RNA fate, including stability, processing, localization, and translation efficiency. Recently, a new RNA 5'-end modification comprising the metabolic effector nicotinamide adenine dinucleotide (NAD) has been identified on RNAs isolated from bacterial, yeast, and human cells. I will discuss the mechanism of NAD capping and the potential role of NAD capping in directly linking cellular metabolism to gene expression.

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