Seminar - Andre Pires da Silva

photo of Dr. Andre Pires da Silva
December 2, 2019 - 12:00pm
Location: 
601 Fairchild

School of Life Sciences

University of Warwick, UK

Host: Oliver Hobert

Title: Energy-sensing pathways mediate intergenerational inheritance.

Abstract: Information sensed by the maternal generation may pass to the offspring to increase their fitness. However, the mechanisms of inheritance of adaptive maternal effects through the germline are largely unknown. We use a new model nematode that offers many advantages for studying this phenomenon, due to the easy-to-score phenotypes, short lifecycle and large reproductive output. We found that environmental stress experienced by the parental generation induces the production of stress-resistant offspring. Environmental signals sensed by neurons send signals to the germline to change its epigenetic and transcriptional profile. The neuronal signals to the germline are mediated by highly conserved energy sensors, raising the possibility that the same mechanism may be present in other organisms that display intergenerational inheritance.  

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