Development of in vivo selection strategies for evolving proteins with novel catalytic properties
Structure & Biophysics
Single molecule mechanics and engineering.
Cryo-electron microscopy and single-particle reconstruction , studying the mechanism of protein biosynthesis and other molecular processes in the cell.
Mechanistic studies of protein synthesis by the ribosome using single-molecule fluorescence microscopy and other biophysical and biochemical approaches
Molecular mechanisms of DNA recombination and repair; single molecule fluorescence microscopy and other biochemical approaches.
Macromolecular structure; X-ray crystallography
Structural biology of transmembrane transport.
Solid-state NMR studies of enzyme mechanism and membrane protein structure
Biomolecular dynamics, structure, and function; NMR spectroscopy
Imaging and Modeling Biology at Physical Extremes.
Diagramming disease networks with chemical and biological tools.
Structural biology of proteins involved in human diseases (obesity, diabetes, cancer); Structural biology of proteins involved in pre-mRNA 3'-end processing.
Department of Biological Sciences
500 Fairchild Center
Mail Code 2401
1212 Amsterdam Avenue
New York, NY 10027