Evolutionary and population genetics of adaptation and disease
We study the evolutionary processes that give rise to genetic and phenotypic differences between individuals, populations and closely related species. Specifically, we use mathematical models to better understand these processes, and statistical analyses to identify their footprints in data and make inferences about them. Our current work focuses primarily on the evolutionary causes of adaptation and disease, but we also study a variety of other topics. To learn more about the lab, visit our website at https://sellalab.biology.columbia.edu.
- Elyashiv E, Sattath S, Hu T, McVicker G, Strutsovsky A, Andolfatto P, Coop G, and G Sella (2016). A genomic map of the effects of linked selection in Drosophila. PLoS Genet 12: e1006130.
- Amster G and G Sella (2016). Life history effects on the molecular clock of autosomes and sex chromosomes. Proc Natl Acad Sci USA 113: 1588-1593.
- Simons Y, Turchin M, Pritchard JK* and G Sella* (2014) The deleterious mutation load is insensitive to recent population history. Nat Genet 46: 220–224.
- Hernandez RD, Kelley JL, Elyashiv E, Melton SC, Auton A, McVean G, 1000 Genomes Project, Sella G* and M Przeworski* (2011) Classic selective sweeps were rare in recent human evolution. Science 331: 920-924.
- Sattath S, Elyavish E, Kolodny O, Rinott Y, and G Sella (2011) Pervasive adaptive protein evolution apparent from diversity patterns around amino-acid substitutions in Drosophila simulans. PLoS Genet 7: e1001302.
- Sella G, Petrov DA, Przeworski M, and P Andolfatto (2009) Evidence for Pervasive Natural Selection in Drosophila? PLoS Genet 5: e1000495.
- Macpherson M+, Sella G+, Davis JC, and DA Petrov (2007) Genome-wide spatial correspondence between non-synonymous divergence and neutral polymorphism reveals extensive adaptation in Drosophila. Genetics 177: 2083-89.
- Sella G and DH Ardell (2006). The Coevolution of Genes and Genetic Codes: Crick’s Frozen Accident Revisited. J Mol Evol 63: 297-313.
- Sella G and AE Hirsh (2005). The Application of Statistical Physics to Evolutionary Biology. Proc Natl Acad Sci USA 102: 9541-9546.
* Joint senior authors.
+ Joint first authors.