University of California, San Francisco
Host: Brent Stockwell
Title: Remodeling of cell surfaceomes in cancer
Abstract: The cell surface proteome is the primary hub for cells to communicate with the outside world. Surface proteins are control buttons that regulate cell growth, nutrient uptake among others, cell-cell contact and signal the immune system if the cell is friend or foe. Once cells become cancerous they undergo tremendous morphological changes (see Figure). My lab studies how the surfacome is remodeled. We find the new set of proteins promote enhanced cell growth and detachment from native tissues allowing metastasis. Our primary goal is to systematically understand how cancer cells remodel their membrane proteomes (surfaceomes) during cancer transformation. We use this information to generate recombinant antibodies, natural proteins that can detect and attack the cancer.