Schuetze Memorial Lecture - Mala Murthy

photo of Dr. Mala Murthy
May 11, 2016 - 12:00pm
Location: 
601 Fairchild

Associate Professor

Princeton Neuroscience Institute

Department of Molecular Biology

Princeton University

Host: Rafael Yuste

Title: Neural Mechanisms for Dynamic Acoustic Communication in Flies

Abstract: Social interactions require continually adjusting behavior in response to sensory feedback. For example, when having a conversation, sensory cues from our partner (e.g., sounds or facial expressions) affect our speech patterns in real time. Our speech signals, in turn, are the sensory cues that modify our partner’s actions. What are the underlying computations and neural mechanisms that govern these interactions? To address these questions, my lab studies the acoustic communication system of Drosophila. To our advantage, the fly nervous system is relatively simple, with a wealth of genetic tools to interrogate it. Importantly, Drosophila acoustic behaviors are highly quantifiable and robust. During courtship, males produce time-varying songs via wing vibration, while females arbitrate mating decisions. We discovered that, rather than being a stereotyped fixed action sequence, male song structure and intensity are continually sculpted by interactions with the female, over timescales ranging from tens of milliseconds to minutes – and we are mapping the underlying circuits and computations. We have also developed methods to relate song representations in the female brain to changes in her behavior, across multiple timescales. Our focus on natural acoustic signals, either as the output of the male nervous system or as the input to the female nervous system, provides a powerful, quantitative handle for studying the basic building blocks of communication.

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